Author(s): Essamaddin Ahmed Abdelhamid Ibrahim
Backgrounds: Helicobacter Pylori is a common pathogen leading cause of peptic ulcer disease. Several studies linked Helicobacter Pylori infection and the development of irritable bowel syndrome. Aims: We investigated the effectiveness of standard triple therapy and the association between H.Pylori infection and the development of post infectious irritable bowel syndrome. Materials and methods: Prospective analytical study was conducted and we appointed 200 H.Pylori positive patients, they consented and subjected to structured questionnaire and received standard triple therapy (14 days course of proton pump inhibitor (PPI), clarithromycin and either amoxicillin or metronidazole). After three months all patients re-evaluated regarding their symptoms and tested for eradication. Additionally we evaluated the association between H.Pylori infection and irritable bowel syndrome. Results: 200 H.Pylori infected patients were participated in this study (57.5%) were females and (42.5%) were males. The mean haemoglobin level was initially 13.89g/dl and the mean platelet level was found to be 289 pre consumption of treatment with statistically insignificant increase haemoglobin and platelets levels post successful eradication (P<0.05). All H.Pylori positive patients followed up after three months and tested for eradication, the majority of the patients – 170 (85%) -successfully eradicate the bacteria. Twenty five patients (12.5%) failed to eradicate the bacteria and five patients failed to follow. Among the cured group 143 patients (71.5%; p<0.05) – appeared to have irritable bowel syndrome according to Rome criteria and considered as post infectious irritable bowel syndrome which was statistically significant. Conclusions: in spite of high prevalence of antibiotics resistance in our country standard triple therapy proved to be effective in H.Pylori eradication. H. pylori infection was significantly associated with irritable bowel syndrome.
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