Author(s): Rajalakshmi G, Subramania Iyer*, Mahija Janardhanan and Krishna Kumar Thankappan
Metastases of a tumour suggests poor prognosis and still treatment strategies against metastatic tumours are inadequate. Its resistance against existing therapeutic agents makes metastatic tumour treatment still challenging. Numerous research work has been done on cancer associated fibroblast (CAF), evidently suggesting of its contribution towards tumour metastasis. Recently a different stromal fibroblast seen in the metastatic sites, characteristically different from CAF known as metastatic associated fibroblast (MAF) has caught attention. Emergent preclinical studies propose that MAF targeting can ease therapeutic resistance and arrest progression of metastatic growth. This review discusses the current knowledge on this novel cell population that may bear on further understanding on the metastatic process.
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